It will be the first of its sites to open outside of Hertfordshire, and will open in the Jericho district of the city.
The 2,750 sq ft restaurant will cater for 80 covers, and the menu will focus on seasonal, local and sustainably-sourced produce. As well as fish, there will be vegan offerings and organically-reared meat dishes.
Lussmanns is the only UK restaurant group to be fully accredited with an MSC-certified wild fish list.
As with its predecessors, the site will “continue to focus on making ethical and sustainable dining accessible on the High Street but will have its own personality and identity fitting with the location”.
Lussmann said it is “possible to be both ethical and profitable” in the hospitality sector, and that a “sustainable ethos lies at the heart of the Lussmanns framework”.
He added: “I’m absolutely delighted to be able to announce that we will be opening in Jericho.
“I’ve always loved this district of Oxford and it seems like the perfect fit, it will be a pleasure to join my thriving peers on this bustling High Street. I’m looking forward to seeing what a new county brings.”
The first Lussmanns opened in 2002 as a small eatery in London, before moving to Hertfordshire two years later to open its first restaurant site.