The new restaurant concept will aim to offer “high-quality great tasting food” at an affordable price point.
The site will open from 10 am -10 pm daily and has a seating capacity of 124.
Jollibee, which originated in the Philippines, said the new opening is in line with the group’s plans to have “at least 50 stores across the UK by 2025”.
The restaurant chain, which has close to 1500 locations around the world, serves fried chicken and Asian-inpsired fast food dishes.
Adam Parkinson, business head of Jollibee Europe, said: “The opening of the restaurant will create new job opportunities for up to 50 people in Cardiff, supporting the local economy and bringing people back to the city centre.
“Since April, trading figures in Cardiff have steadily grown with more people coming into work and growing confidence in the hospitality sector.”